Journal: ALTEX

Article Title: Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups

doi: 10.14573/altex.1703231

Figure Lengend Snippet: Results of Case Study 1: Comparison of ToxCast AC50s (in microM) for nuclear-receptor-related assays between PFOA (including its ammonium salt) and selected “prototypical” compounds DEHP (including its metabolite MEHP), phenobarbital, and rifampicin. Longer bar indicates greater potency (lower AC50). Assays for which all compounds were negative are not displayed. See Supplemental Materials for the assay endpoints corresponding to the abbreviations shown.

Article Snippet: It should be noted however, that observed activity of PFOA and its ammonium salt in many, albeit not all, in vitro assays evaluated herein may be also attributed to their surfactant properties, a limitation of in vitro screening described in ( Sipes et al., 2013 ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window caption a7 Results of Case Study 1: Comparison of ToxCast AC50s (in microM) for nuclear-receptor-related assays between PFOA (including its ammonium salt) and selected “prototypical” compounds DEHP (including its metabolite MEHP), phenobarbital, and rifampicin.

Techniques: Comparison